CSF1R over exp
Gene Variant Detail

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Gene CSF1R
Variant over exp
Impact List none
Protein Effect no effect
Gene Variant Descriptions CSF1R over exp indicates an over expression of the Csf1r protein. However, the mechanism causing the over expression is unspecified.
Associated Drug Resistance
Category Variants Paths

CSF1R over exp

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No Variant Reference Transcript is Available.
No transcript is Available.

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
CSF1R over exp tenosynovial giant cell tumor sensitive Pexidartinib Phase I Actionable In a Phase I trial, PLX3397 reduced tenosynovial giant cell tumor volume in patients with overexpression of Csf1r (PMID: 26222558). 26222558
CSF1R over exp acute myeloid leukemia sensitive Narazaciclib Preclinical - Pdx & cell culture Actionable In a preclinical study, Narazaciclib (ON123300) inhibited proliferation of acute myeloid leukemia cell lines harboring CSF1R overexpression in culture, and decreased the leukemic burden in the spleen and bone in a patient-derived xenograft (PDX) model (PMID: 38641704). 38641704
CSF1R over exp acute myeloid leukemia sensitive Cytarabine + Narazaciclib Preclinical - Pdx Actionable In a preclinical study, treatment with the combination of Narazaciclib (ON123300) and Cytosar-U (cytarabine) reduced tumor burden in a patient-derived xenograft (PDX) model of acute myeloid leukemia with CSF1R overexpression (PMID: 38641704). 38641704