BRAF V600X
Gene Variant Detail

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Gene BRAF
Variant V600X
Impact List missense
Protein Effect unknown
Gene Variant Descriptions BRAF V600X indicates any BRAF missense mutation that results in replacement of the valine (V) at amino acid 600 by a different amino acid. BRAF V600 mutations are hotspot mutations that often result in increased Braf kinase activity (PMID: 15035987).
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF V600X

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Transcript NM_004333.6
gDNA chr7:g.140753335_140753337
cDNA c.1798_1800
Protein p.V600
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001378468.1 chr7:g.140753335_140753337 c.1798_1800 p.V600 RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140753335_140753337 c.1798_1800 p.V600 RefSeq GRCh38/hg38
NM_004333 chr7:g.140753335_140753337 c.1798_1800 p.V600 RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140753335_140753337 c.1798_1800 p.V600 RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140753335_140753337 c.1798_1800 p.V600 RefSeq GRCh38/hg38
XM_005250045 chr7:g.140753335_140753337 c.1798_1800 p.V600 RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140753335_140753337 c.1798_1800 p.V600 RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140753335_140753337 c.1798_1800 p.V600 RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Protein Effect Treatment Approaches
BRAF V600X unknown BRAF Inhibitor MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor RAF Inhibitor (Pan)
BRAF V600X PIK3CA H1047X
BRAF V600X MAP2K1 V60E NRAS T58I NRAS Q61R
BRAF V600X BRAF amp NRAS Q61K
BRAF V600X PTEN H93D
BRAF V600X PTEN neg
BRAF V600X PIK3CA H1047R PTEN Y68fs
BRAF V600X NRAS mut