NTRK2 rearrange
Gene Variant Detail

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Gene NTRK2
Variant rearrange
Impact List unknown
Protein Effect unknown
Gene Variant Descriptions NTRK2 rearrangement indicates an unspecified rearrangement of the NTRK2 gene.
Associated Drug Resistance
Category Variants Paths

NTRK2 mutant NTRK2 rearrange

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No Variant Reference Transcript is Available.
No transcript is Available.

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
NTRK2 rearrange Advanced Solid Tumor predicted - sensitive Entrectinib Clinical Study Actionable In a clinical study, Rozlytrek (entrectinib) treatment resulted in objective response in 75% (3/4) of patients with advanced solid tumors harboring rearrangement in NTRK1, NTRK2, or NTRK3 genes (AACR Apr 2016, Abstract # CT007). detail...
NTRK2 rearrange sarcoma sensitive Entrectinib Guideline Actionable Rozlytrek (entrectinib) is included in guidelines as a standard treatment for patients with advanced sarcomas harboring NTRK rearrangement (PMID: 34303806; ESMO.org). detail... 34303806
NTRK2 rearrange sarcoma sensitive Larotrectinib Guideline Actionable Vitrakvi (larotrectinib) is included in guidelines as a standard treatment for patients with advanced sarcomas harboring NTRK rearrangement (PMID: 34303806; ESMO.org). detail... 34303806