ALK L1198F
Gene Variant Detail

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Gene ALK
Variant L1198F
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions ALK L1198F lies within the protein kinase domain of the Alk protein (UniProt.org). L1198F confers a gain of function to the Alk protein as demonstrated by increased Alk kinase activity in an in vitro assay and increased Akt and Erk phosphorylation, cell invasion, and transformation in culture (PMID: 21596819).
Associated Drug Resistance
Category Variants Paths

ALK mutant ALK act mut ALK L1198F

ALK mutant ALK L1198X ALK L1198F

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Transcript NM_004304.5
gDNA chr2:g.29220759G>A
cDNA c.3592C>T
Protein p.L1198F
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004304 chr2:g.29220759G>A c.3592C>T p.L1198F RefSeq GRCh38/hg38
NM_004304.5 chr2:g.29220759G>A c.3592C>T p.L1198F RefSeq GRCh38/hg38
NM_004304.4 chr2:g.29220759G>A c.3592C>T p.L1198F RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
ALK rearrange ALK L1198F ALK mut
ALK L1198F gain of function ALK Inhibitor
ALK rearrange ALK C1156Y ALK L1198F
EML4 - ALK ALK C1156Y ALK L1198F Crizotinib
EML4 - ALK ALK L1198F Brigatinib Crizotinib
EML4 - ALK ALK F1174C ALK L1198F Crizotinib
EML4 - ALK ALK L1196M ALK L1198F
EML4 - ALK ALK L1198F ALK G1202R Crizotinib
EML4 - ALK ALK L1198F ALK G1269A Brigatinib Crizotinib
ALK rearrange ALK I1171N ALK L1198F
ALK rearrange ALK L1198F
EML4 - ALK ALK L1198F ALK G1202R ALK G1269A
EML4 - ALK ALK I1171N ALK L1198F
ALK C1156Y ALK L1198F
ALK L1196M ALK L1198F
ALK L1198F ALK G1202R
ALK fusion ALK C1156Y ALK L1198F
EML4 - ALK ALK C1156Y ALK I1171N ALK L1198F
EML4 - ALK ALK C1156Y ALK I1171T ALK L1198F