AXL A273V
Gene Variant Detail

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Gene AXL
Variant A273V
Impact List missense
Protein Effect unknown
Gene Variant Descriptions AXL A273V lies within fibronectin type-III domain 1 of the Axl protein (UniProt.org). A273V has been associated with resistance to EGFR inhibitors (Cancer Res 2018;78(13 Suppl): nr 4903), but has not been biochemically characterized and therefore, its effect on Axl protein function is unknown (PubMed, Jan 2026).
Associated Drug Resistance Y
Category Variants Paths

AXL mutant AXL A273V

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Transcript NM_021913.5
gDNA chr19:g.41237978C>T
cDNA c.818C>T
Protein p.A273V
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001699 chr19:g.41237978C>T c.818C>T p.A273V RefSeq GRCh38/hg38
NM_001699.5 chr19:g.41237978C>T c.818C>T p.A273V RefSeq GRCh38/hg38
NM_001699.6 chr19:g.41237978C>T c.818C>T p.A273V RefSeq GRCh38/hg38
NM_021913 chr19:g.41237978C>T c.818C>T p.A273V RefSeq GRCh38/hg38
NM_021913.4 chr19:g.41237978C>T c.818C>T p.A273V RefSeq GRCh38/hg38
NM_021913.5 chr19:g.41237978C>T c.818C>T p.A273V RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
AXL A273V lung non-small cell carcinoma predicted - resistant Erlotinib Preclinical - Cell culture Actionable In a preclinical study, expression of AXL A273V in non-small cell lung cancer cells conferred resistance to Tarceva (erlotinib) in culture (Cancer Res 2018;78(13 Suppl): nr 4903). detail...