RAD51C T287A
Gene Variant Detail

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Gene RAD51C
Variant T287A
Impact List missense
Protein Effect unknown
Gene Variant Descriptions RAD51C T287A does not lie within any known functional domains of the Rad51c protein (UniProt.org). T287A is conflicting as it demonstrates homologous recombination activity similar to wild-type Rad51c in cultured cells, rescues survival in Rad51c-null cells in culture, and results in variable interaction with Rad51b, Rad51d, and Xrcc3 in one study (PMID: 36099300), but demonstrates a partial defect in homologous recombination (PMID: 22167183, PMID: 21980511, PMID: 25292178) and decreased association with Xrcc3 in other studies (PMID: 22167183, PMID: 21980511), and therefore, its effect on Rad51c protein function is unknown.
Associated Drug Resistance
Category Variants Paths

RAD51C mutant RAD51C T287A

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Transcript NM_058216.3
gDNA chr17:g.58720767A>G
cDNA c.859A>G
Protein p.T287A
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006722002 chr17:g.58720767A>G c.859A>G p.T287A RefSeq GRCh38/hg38
NM_058216 chr17:g.58720767A>G c.859A>G p.T287A RefSeq GRCh38/hg38
NM_058216.2 chr17:g.58720767A>G c.859A>G p.T287A RefSeq GRCh38/hg38
XM_006722002.4 chr17:g.58720767A>G c.859A>G p.T287A RefSeq GRCh38/hg38
XM_006722001.5 chr17:g.58720767A>G c.859A>G p.T287A RefSeq GRCh38/hg38
XM_006722002.5 chr17:g.58720767A>G c.859A>G p.T287A RefSeq GRCh38/hg38
XM_006722001 chr17:g.58720767A>G c.859A>G p.T287A RefSeq GRCh38/hg38
XM_006722001.4 chr17:g.58720767A>G c.859A>G p.T287A RefSeq GRCh38/hg38
NM_058216.3 chr17:g.58720767A>G c.859A>G p.T287A RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RAD51C mutant breast cancer not applicable N/A Guideline Risk Factor Germline RAD51C mutations are associated with increased risk of developing breast cancer (NCCN.org). detail...
RAD51C mutant ovarian serous carcinoma predicted - sensitive Olaparib Case Reports/Case Series Actionable In a clinical case study, Lynparza (olaparib) treatment resulted in a complete response with treatment ongoing at 14 months in a patient with relapsed, metastatic high grade serous ovarian carcinoma harboring RAD51C mutations (PMID: 36176748). 36176748
RAD51C mutant ovarian cancer not applicable N/A Guideline Risk Factor Germline RAD51C mutations are associated with increased risk of developing ovarian cancer (NCCN.org). detail...