MST1R over exp
Gene Variant Detail

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Gene MST1R
Variant over exp
Impact List none
Protein Effect no effect
Gene Variant Descriptions MST1R over exp indicates an over expression of the Mst1r protein. However, the mechanism causing the over expression is unspecified.
Associated Drug Resistance
Category Variants Paths

MST1R over exp

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No Variant Reference Transcript is Available.
No transcript is Available.

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
MST1R over exp colon cancer predicted - sensitive IMC-41A10 Preclinical - Cell line xenograft Actionable In a preclinical study, IMC-41A10 inhibited MST1R (RON) downstream signaling and migration of colon cancer cells in culture, and reduced tumor growth in MST1R-positive colorectal cancer xenograft models (PMID: 16982759). 16982759
MST1R over exp urinary bladder cancer decreased response Epirubicin Preclinical - Cell culture Actionable In a preclinical study, MST1R (RON) over expression resulted in decreased sensitivity to Ellence (epirubicin) in bladder cancer cells under hypoxia in culture, resulting in increased cell survival (PMID: 26772202). 26772202