Molecular Profile Detail

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Profile Name MST1R over exp
Gene Variant Detail

MST1R over exp (no effect)

Relevant Treatment Approaches RON Inhibitor IMC-41A10 Narnatumab Zt/f2 Zt/g4 Zt/g4-DM1

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
MST1R over exp colon cancer predicted - sensitive IMC-41A10 RON Inhibitor IMC-41A10 Preclinical - Cell line xenograft Actionable In a preclinical study, IMC-41A10 inhibited MST1R (RON) downstream signaling and migration of colon cancer cells in culture, and reduced tumor growth in MST1R-positive colorectal cancer xenograft models (PMID: 16982759). 16982759
MST1R over exp urinary bladder cancer decreased response Epirubicin Preclinical - Cell culture Actionable In a preclinical study, MST1R (RON) over expression resulted in decreased sensitivity to Ellence (epirubicin) in bladder cancer cells under hypoxia in culture, resulting in increased cell survival (PMID: 26772202). 26772202