NTRK2 R715G
Gene Variant Detail

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Gene NTRK2
Variant R715G
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions NTRK2 R715G (corresponds to R699G in the canonical isoform) lies within the protein kinase domain of the Ntrk2 protein (UniProt.org). R715G demonstrates decreased autophosphorylation and phosphorylation of Ntrk2, Akt and Erk upon growth factor stimulation, does not support anchorage independent growth, and is associated with resistance to a Trk inhibitor in culture (PMID: 21242122).
Associated Drug Resistance Y
Category Variants Paths

NTRK2 mutant NTRK2 inact mut NTRK2 R715G

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Transcript NM_006180.6
gDNA chr9:g.84955488C>G
cDNA c.2143C>G
Protein p.R715G
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_005252004.3 chr9:g.84955488C>G c.2143C>G p.R715G RefSeq GRCh38/hg38
XM_005252001 chr9:g.84955488C>G c.2143C>G p.R715G RefSeq GRCh38/hg38
XM_017014751.2 chr9:g.84955488C>G c.2143C>G p.R715G RefSeq GRCh38/hg38
XM_005252003.4 chr9:g.84955488C>G c.2143C>G p.R715G RefSeq GRCh38/hg38
NM_006180 chr9:g.84955488C>G c.2143C>G p.R715G RefSeq GRCh38/hg38
XM_047423432.1 chr9:g.84955488C>G c.2143C>G p.R715G RefSeq GRCh38/hg38
XM_005252003 chr9:g.84955488C>G c.2143C>G p.R715G RefSeq GRCh38/hg38
NM_006180.4 chr9:g.84955488C>G c.2143C>G p.R715G RefSeq GRCh38/hg38
XM_005252004 chr9:g.84955488C>G c.2143C>G p.R715G RefSeq GRCh38/hg38
XM_047423433.1 chr9:g.84955488C>G c.2143C>G p.R715G RefSeq GRCh38/hg38
XM_005252003.3 chr9:g.84955488C>G c.2143C>G p.R715G RefSeq GRCh38/hg38
XM_017014751 chr9:g.84955488C>G c.2143C>G p.R715G RefSeq GRCh38/hg38
XM_005252004.2 chr9:g.84955488C>G c.2143C>G p.R715G RefSeq GRCh38/hg38
XM_005252001.3 chr9:g.84955488C>G c.2143C>G p.R715G RefSeq GRCh38/hg38
XM_017014751.3 chr9:g.84955488C>G c.2143C>G p.R715G RefSeq GRCh38/hg38
XM_005252001.4 chr9:g.84955488C>G c.2143C>G p.R715G RefSeq GRCh38/hg38
NM_006180.6 chr9:g.84955488C>G c.2143C>G p.R715G RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
NTRK2 R715G Advanced Solid Tumor resistant AZD6918 Preclinical Actionable In a preclinical study, a transformed cell line expressing NTRK2 R715G was resistant to inhibition of Ntrk2 autophosphorylation and BDNF-induced cell proliferation by AZD6918 treatment in culture (PMID: 21242122). 21242122