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TP53 Y234C - Gene Variant Detail

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Gene TP53
Variant Y234C
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions TP53 Y234C lies within the DNA-binding domain of the Tp53 protein (PMID: 22713868). Y234C results in decreased Tp53 transactivation and interferes with wild-type Tp53 function in cell culture, and correlates with protein aggregates in human tumor samples (PMID: 21056685, PMID: 16861262).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon7 TP53 Y234C

TP53 mutant TP53 inact mut TP53 Y234C

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Transcript NM_000546.6
gDNA chr17:g.7674262T>C
cDNA c.701A>G
Protein p.Y234C
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001126113.2 chr17:g.7674262T>C c.701A>G p.Y234C RefSeq GRCh38/hg38
NM_000546 chr17:g.7674262T>C c.701A>G p.Y234C RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7674262T>C c.701A>G p.Y234C RefSeq GRCh38/hg38
NM_001126113 chr17:g.7674262T>C c.701A>G p.Y234C RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7674262T>C c.701A>G p.Y234C RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7674262T>C c.701A>G p.Y234C RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7674262T>C c.701A>G p.Y234C RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7674262T>C c.701A>G p.Y234C RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7674262T>C c.701A>G p.Y234C RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7674262T>C c.701A>G p.Y234C RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7674262T>C c.701A>G p.Y234C RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7674262T>C c.701A>G p.Y234C RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7674262T>C c.701A>G p.Y234C RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7674262T>C c.701A>G p.Y234C RefSeq GRCh38/hg38
NM_001126112 chr17:g.7674262T>C c.701A>G p.Y234C RefSeq GRCh38/hg38
NM_001126114 chr17:g.7674262T>C c.701A>G p.Y234C RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7674262T>C c.701A>G p.Y234C RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
TP53 Y234C ovarian carcinoma sensitive ReACp53 Preclinical Actionable In a preclinical study, ReACp53 induced cell death in human primary ovarian carcinoma cells harboring TP53 Y234C in culture (PMID: 26748848). 26748848
TP53 Y234C lung non-small cell carcinoma decreased response Seliciclib Preclinical - Cell culture Actionable In a preclinical study, non-small cell lung carcinoma cells overexpressing TP53 Y234C demonstrated reduced sensitivity to Roscovotine (seliciclib) induced apoptosis in culture (PMID: 22862161). 22862161