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Gene RAD51C
Variant T5R
Impact List missense
Protein Effect unknown
Gene Variant Descriptions RAD51C T5R lies within a region of the Rad51c protein required for Holliday junction resolution activity (UniProt.org). T5R has not been characterized in the scientific literature and therefore, its effect on Rad51c protein function is unknown (PubMed, Oct 2024).
Associated Drug Resistance
Category Variants Paths

RAD51C mutant RAD51C T5R

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Transcript NM_058216.3
gDNA chr17:g.58692657C>G
cDNA c.14C>G
Protein p.T5R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_058216.3 chr17:g.58692657C>G c.14C>G p.T5R RefSeq GRCh38/hg38
NM_058216.2 chr17:g.58692657C>G c.14C>G p.T5R RefSeq GRCh38/hg38
NM_002876 chr17:g.58692657C>G c.14C>G p.T5R RefSeq GRCh38/hg38
XM_047436505.1 chr17:g.58692657C>G c.14C>G p.T5R RefSeq GRCh38/hg38
XM_006722002.4 chr17:g.58692657C>G c.14C>G p.T5R RefSeq GRCh38/hg38
NM_002876.3 chr17:g.58692657C>G c.14C>G p.T5R RefSeq GRCh38/hg38
XM_006722001 chr17:g.58692657C>G c.14C>G p.T5R RefSeq GRCh38/hg38
XM_006722001.4 chr17:g.58692657C>G c.14C>G p.T5R RefSeq GRCh38/hg38
XM_006722002.5 chr17:g.58692657C>G c.14C>G p.T5R RefSeq GRCh38/hg38
NM_002876.4 chr17:g.58692657C>G c.14C>G p.T5R RefSeq GRCh38/hg38
XM_006722002 chr17:g.58692657C>G c.14C>G p.T5R RefSeq GRCh38/hg38
NM_058216 chr17:g.58692657C>G c.14C>G p.T5R RefSeq GRCh38/hg38
XM_006722001.5 chr17:g.58692657C>G c.14C>G p.T5R RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RAD51C mutant breast cancer not applicable N/A Guideline Risk Factor Germline RAD51C mutations are associated with increased risk of developing breast cancer (NCCN.org). detail...
RAD51C mutant ovarian serous carcinoma predicted - sensitive Olaparib Case Reports/Case Series Actionable In a clinical case study, Lynparza (olaparib) treatment resulted in a complete response with treatment ongoing at 14 months in a patient with relapsed, metastatic high grade serous ovarian carcinoma harboring RAD51C mutations (PMID: 36176748). 36176748
RAD51C mutant ovarian cancer not applicable N/A Guideline Risk Factor Germline RAD51C mutations are associated with increased risk of developing ovarian cancer (NCCN.org). detail...