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Gene DNMT3A
Variant F731fs
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions DNMT3A F731fs results in a change in the amino acid sequence of the Dnmt3a protein beginning at aa 731 of 912, likely resulting in premature truncation of the functional protein (UniProt.org). F731fs has not been characterized, however, due to the effects of other truncation mutations downstream of F731 (PMID: 35639959), is predicted to lead to a loss of Dnmt3a protein function.
Associated Drug Resistance
Category Variants Paths

DNMT3A mutant DNMT3A inact mut DNMT3A F731fs

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Transcript NM_022552.5
gDNA chr2:g.(25240433_25240434)
cDNA c.(2191_2190)
Protein p.F731fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_175629.2 chr2:g.(25240433_25240434) c.(2191_2190) p.F731fs RefSeq GRCh38/hg38
XM_005264175.6 chr2:g.(25240433_25240434) c.(2191_2190) p.F731fs RefSeq GRCh38/hg38
XM_011532664.3 chr2:g.(25240433_25240434) c.(2191_2190) p.F731fs RefSeq GRCh38/hg38
XM_017003526 chr2:g.(25240433_25240434) c.(2191_2190) p.F731fs RefSeq GRCh38/hg38
NM_022552 chr2:g.(25240433_25240434) c.(2191_2190) p.F731fs RefSeq GRCh38/hg38
NM_175629.2 chr2:g.(25240433_25240434) c.(2191_2190) p.F731fs RefSeq GRCh38/hg38
XM_017003526.2 chr2:g.(25240433_25240434) c.(2191_2190) p.F731fs RefSeq GRCh38/hg38
NM_022552.4 chr2:g.(25240433_25240434) c.(2191_2190) p.F731fs RefSeq GRCh38/hg38
XM_017003526.1 chr2:g.(25240433_25240434) c.(2191_2190) p.F731fs RefSeq GRCh38/hg38
XM_005264175.5 chr2:g.(25240433_25240434) c.(2191_2190) p.F731fs RefSeq GRCh38/hg38
XM_011532664.2 chr2:g.(25240433_25240434) c.(2191_2190) p.F731fs RefSeq GRCh38/hg38
NM_022552.5 chr2:g.(25240433_25240434) c.(2191_2190) p.F731fs RefSeq GRCh38/hg38
NM_175629 chr2:g.(25240433_25240434) c.(2191_2190) p.F731fs RefSeq GRCh38/hg38
XM_011532664 chr2:g.(25240433_25240434) c.(2191_2190) p.F731fs RefSeq GRCh38/hg38
XM_047443593.1 chr2:g.(25240433_25240434) c.(2191_2190) p.F731fs RefSeq GRCh38/hg38
XM_005264175 chr2:g.(25240433_25240434) c.(2191_2190) p.F731fs RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
DNMT3A mutant angioimmunoblastic T-cell lymphoma not applicable N/A Guideline Diagnostic DNMT3A mutations aid in the diagnosis of angioimmunoblastic T-cell lymphoma (NCCN.org). detail...
DNMT3A mutant acute myeloid leukemia not applicable N/A Clinical Study Prognostic In clinical analyses, mutations in DNMT3A were associated with poor prognosis and shorter overall survival in patients with acute myeloid leukemia (PMID: 22490330, PMID: 21881046, PMID: 21670448). 22490330 21881046 21670448
DNMT3A mutant acute myeloid leukemia predicted - sensitive Decitabine Clinical Study - Cohort Actionable In a clinical study, acute myeloid leukemia patients harboring DNMT3A mutations demonstrated a greater complete response rate (60% vs 33%) compared to patients with wild-type DNMT3A when treated with frontline hypomethylating agents such as Dacogen (decitabine) (PMID: 27418649). 27418649
DNMT3A mutant acute myeloid leukemia resistant Olaparib Preclinical - Patient cell culture Actionable In a preclinical study, patient-derived acute myeloid leukemia cells harboring a DNMT3A mutation along with FLT3-ITD and NPM1 mutation were resistant to Lynparza (olaparib) in culture (PMID: 34215619). 34215619
DNMT3A mutant acute myeloid leukemia sensitive Pinometostat Preclinical - Cell line xenograft Actionable In a preclinical study, Pinometostat (EPZ-5676) treatment of acute myeloid leukemia cell lines and xenografts resulted in apoptosis, cell-cycle arrest, and terminal differentiation (PMID: 27335278). 27335278
DNMT3A mutant myelofibrosis not applicable N/A Guideline Prognostic DNMT3A mutations are associated with inferior overall survival in patients with primary myelofibrosis (NCCN.org). detail...