ALK E1210K
Gene Variant Detail

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Gene ALK
Variant E1210K
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ALK E1210K lies within the protein kinase domain of the Alk protein (UniProt.org). E1210K has been demonstrated to occur as a secondary drug resistance mutation in the context of ALK fusions (PMID: 29650534, PMID: 35123209, PMID: 27432227), but has not been biochemically characterized and therefore, its effect on Alk protein function is unknown (PubMed, Nov 2025).
Associated Drug Resistance Y
Category Variants Paths

ALK mutant ALK E1210K

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Transcript NM_004304.5
gDNA chr2:g.29220723C>T
cDNA c.3628G>A
Protein p.E1210K
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004304.5 chr2:g.29220723C>T c.3628G>A p.E1210K RefSeq GRCh38/hg38
NM_004304 chr2:g.29220723C>T c.3628G>A p.E1210K RefSeq GRCh38/hg38
NM_004304.4 chr2:g.29220723C>T c.3628G>A p.E1210K RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ALK E1210K Advanced Solid Tumor predicted - sensitive TPX-0131 Preclinical - Biochemical Actionable In a preclinical study, TPX-0131 inhibited kinase activity of ALK E1210K in an in vitro assay (PMID: 34158340). 34158340
ALK E1210K lung non-small cell carcinoma predicted - resistant Ensartinib Case Reports/Case Series Actionable In a clinical case study, a patient with non-small cell lung cancer progressed on Ensacove (ensartinib) treatment and was found to have acquired ALK E1210K and lost ALK L1152V and G1269A in plasma cell-free DNA (PMID: 31446141). 31446141