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RET C609Y - Gene Variant Detail

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Gene RET
Variant C609Y
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions RET C609Y lies within the extracellular domain of the Ret protein (UniProt.org). C609Y results in constitutive activation of Ret, increased resistance to apoptosis, transformation of cultured cells, and enhanced tumor growth in mouse models (PMID: 16715139, PMID: 9230192).
Associated Drug Resistance
Category Variants Paths

RET mutant RET act mut RET C609Y

RET mutant RET C609X RET C609Y

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Transcript NM_020975.6
gDNA chr10:g.43113622G>A
cDNA c.1826G>A
Protein p.C609Y
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_020975.5 chr10:g.43113622G>A c.1826G>A p.C609Y RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43113622G>A c.1826G>A p.C609Y RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43113622G>A c.1826G>A p.C609Y RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43113622G>A c.1826G>A p.C609Y RefSeq GRCh38/hg38
NM_001406763.1 chr10:g.43113622G>A c.1826G>A p.C609Y RefSeq GRCh38/hg38
NM_020975 chr10:g.43113622G>A c.1826G>A p.C609Y RefSeq GRCh38/hg38
NM_020630 chr10:g.43113622G>A c.1826G>A p.C609Y RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43113622G>A c.1826G>A p.C609Y RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43113622G>A c.1826G>A p.C609Y RefSeq GRCh38/hg38
NM_001406765.1 chr10:g.43113622G>A c.1826G>A p.C609Y RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43113622G>A c.1826G>A p.C609Y RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43113622G>A c.1826G>A p.C609Y RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References