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Gene RET
Variant D631_L633delinsE
Impact List indel
Protein Effect unknown
Gene Variant Descriptions RET D631_L633delinsE results in a deletion of three amino acids in the extracellular domain of the Ret protein from amino acids 631 to 633, combined with the insertion of one glutamic acid (E) at the same site (UniProt.org). D631_L633delinsE has been identified in the scientific literature (PMID: 27082517), but has not been biochemically characterized and therefore, its effect on Ret protein function is unknown (PubMed, Jun 2024).
Associated Drug Resistance
Category Variants Paths

RET mutant RET D631_L633delinsE

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Transcript NM_020975.6
gDNA chr10:g.43114493_43114498delCGAGCT
cDNA c.1893_1898delCGAGCT
Protein p.D631_L633delinsE
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_020975.6 chr10:g.43114493_43114498delCGAGCT c.1893_1898delCGAGCT p.D631_L633delinsE RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43114493_43114498delCGAGCT c.1893_1898delCGAGCT p.D631_L633delinsE RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43114493_43114498delCGAGCT c.1893_1898delCGAGCT p.D631_L633delinsE RefSeq GRCh38/hg38
NM_020630 chr10:g.43114493_43114498delCGAGCT c.1893_1898delCGAGCT p.D631_L633delinsE RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43114493_43114498delCGAGCT c.1893_1898delCGAGCT p.D631_L633delinsE RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43114493_43114498delCGAGCT c.1893_1898delCGAGCT p.D631_L633delinsE RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43114493_43114498delCGAGCT c.1893_1898delCGAGCT p.D631_L633delinsE RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43114493_43114498delCGAGCT c.1893_1898delCGAGCT p.D631_L633delinsE RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43114493_43114498delCGAGCT c.1893_1898delCGAGCT p.D631_L633delinsE RefSeq GRCh38/hg38
NM_020975 chr10:g.43114493_43114498delCGAGCT c.1893_1898delCGAGCT p.D631_L633delinsE RefSeq GRCh38/hg38

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RET D631_L633delinsE Advanced Solid Tumor sensitive Selpercatinib Preclinical - Cell culture Actionable In a preclinical study, Retevmo (selpercatinib) inhibited viability in transformed cells expressing RET D631_L633delinsE in culture (PMID: 36166639). 36166639
RET D631_L633delinsE Advanced Solid Tumor sensitive Pralsetinib Preclinical - Cell culture Actionable In a preclinical study, Gavreto (pralsetinib) inhibited viability in transformed cells expressing RET D631_L633delinsE in culture (PMID: 36166639). 36166639