PMS2 loss
Gene Variant Detail

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Gene PMS2
Variant loss
Impact List unknown
Protein Effect loss of function
Gene Variant Descriptions PMS2 loss indicates loss of the PMS2 gene, mRNA, and protein.
Associated Drug Resistance
Category Variants Paths

PMS2 mutant PMS2 inact mut PMS2 loss

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No Variant Reference Transcript is Available.
No transcript is Available.

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PMS2 loss colorectal cancer decreased response unspecified immune checkpoint inhibitor Clinical Study - Cohort Actionable In a retrospective analysis, treatment with Keytruda (pembrolizumab), Opdivo (nivolumab), or the combination of Opdivo (nivolumab) and Yervoy (ipilimumab) in patients with mismatch repair-deficient colorectal cancer harboring PMS2 loss or MLH1 and PMS2 loss versus patients with MSH6 loss or MSH2 and MSH6 loss resulted in a similar objective response rate (70.6% vs. 60.0%), but resulted in shorter progression-free survival (PFS) rates (1-year PFS 57.8% vs. 84.2%, 2-year PFS 54.2% vs. 78.2%) (PMID: 33631043). 33631043