Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
Profile Name | PMS2 loss |
Gene Variant Detail | |
Relevant Treatment Approaches |
Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|---|
PMS2 loss | colorectal cancer | decreased response | unspecified immune checkpoint inhibitor | Clinical Study - Cohort | Actionable | In a retrospective analysis, treatment with Keytruda (pembrolizumab), Opdivo (nivolumab), or the combination of Opdivo (nivolumab) and Yervoy (ipilimumab) in patients with mismatch repair-deficient colorectal cancer harboring PMS2 loss or MLH1 and PMS2 loss versus patients with MSH6 loss or MSH2 and MSH6 loss resulted in a similar objective response rate (70.6% vs. 60.0%), but resulted in shorter progression-free survival (PFS) rates (1-year PFS 57.8% vs. 84.2%, 2-year PFS 54.2% vs. 78.2%) (PMID: 33631043). | 33631043 |