ALK F1245I
Gene Variant Detail

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Gene ALK
Variant F1245I
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ALK F1245I lies within the protein kinase domain of the Alk protein (UniProt.org). F1245I has been identified in the scientific literature (PMID: 30778092, PMID: 34282791, PMID: 37523146), but has not been biochemically characterized and therefore, its effect on Alk protein function is unknown (PubMed, Nov 2025).
Associated Drug Resistance
Category Variants Paths

ALK mutant ALK F1245X ALK F1245I

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Transcript NM_004304.5
gDNA chr2:g.29213994A>T
cDNA c.3733T>A
Protein p.F1245I
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004304.4 chr2:g.29213994A>T c.3733T>A p.F1245I RefSeq GRCh38/hg38
NM_004304.5 chr2:g.29213994A>T c.3733T>A p.F1245I RefSeq GRCh38/hg38
NM_004304 chr2:g.29213994A>T c.3733T>A p.F1245I RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ALK F1245I neuroblastoma sensitive Lorlatinib Case Reports/Case Series Actionable In a clinical case study, Lorbrena (lorlatinib) treatment resulted in a partial response in a pediatric patient with neuroblastoma harboring ALK F1245I, and in a preclinical study, induced response in a patient-derived xenograft (PDX) mouse model and zebrafish model (PMID: 40637158). 40637158
ALK F1245I neuroblastoma sensitive Lorlatinib Case Reports/Case Series Actionable In a clinical study, Lorbrena (lorlatinib) treatment resulted in a partial response in a pediatric patient with neuroblastoma harboring ALK F1245I, inhibited viability of patient-derived cells in culture, decreased tumor growth and prolonged event-free survival in a patient-derived xenograft model (PMID: 37523146; NCT03336931). 37523146
ALK F1245I neuroblastoma sensitive Ceritinib Preclinical - Pdx & cell culture Actionable In a preclinical study, Zykadia (ceritinib) inhibited viability of patient-derived neuroblastoma cells harboring ALK F1245I in culture and inhibited tumor growth in a patient-derived xenograft model (PMID: 37523146). 37523146
ALK F1245I neuroblastoma sensitive Crizotinib Preclinical - Pdx & cell culture Actionable In a preclinical study, Xalkori (crizotinib) inhibited viability of patient-derived neuroblastoma cells harboring ALK F1245I in culture, inhibited tumor growth, and prolonged event-free survival in a patient-derived xenograft model (PMID: 37523146). 37523146
ALK F1245I neuroblastoma sensitive Alectinib Preclinical - Pdx & cell culture Actionable In a preclinical study, Alecensa (alectinib) inhibited viability of patient-derived neuroblastoma cells harboring ALK F1245I in culture, inhibited tumor growth, and prolonged event-free survival in a patient-derived xenograft model (PMID: 37523146). 37523146