MERTK positive
Gene Variant Detail

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Gene MERTK
Variant positive
Impact List unknown
Protein Effect unknown
Gene Variant Descriptions MERTK positive indicates the presence of MERTK mRNA and/or protein.
Associated Drug Resistance
Category Variants Paths

MERTK positive

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No Variant Reference Transcript is Available.
No transcript is Available.

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
MERTK positive acute lymphoblastic leukemia sensitive UNC2025 Preclinical - Patient cell culture Actionable In a preclinical study, UNC2025 inhibited Mertk signaling, resulted in apoptosis and growth inhibition of patient-derived acute lymphocytic leukemia cells in culture, and prolonged survival in orthotopic murine xenograft models (PMID: 27649555). 27649555
MERTK positive acute myeloid leukemia sensitive UNC2025 Preclinical - Pdx & cell culture Actionable In a preclinical study, UNC2025 inhibited Mertk signaling, resulted in apoptosis and growth inhibition of patient-derived acute lymphocytic leukemia cells in culture, and prolonged survival in patient-derived xenograft models (PMID: 27649555). 27649555
MERTK positive acute lymphoblastic leukemia sensitive Methotrexate + UNC2025 Preclinical - Cell line xenograft Actionable In a preclinical study, combination of UNC2025 and Methotrexate resulted in improved tumor suppression and survival compared to single agent treatment in cell line xenograft models of acute lymphocytic leukemia (PMID: 27649555). 27649555
MERTK positive acute myeloid leukemia sensitive UNC569 Preclinical - Cell culture Actionable In a preclinical study, UNC569 inhibited Mertk phosphorylation and downstream signaling, resulted in growth inhibition of acute myeloid leukemia cell lines in culture (PMID: 29277773). 29277773
MERTK positive acute myeloid leukemia sensitive UNC1062 Preclinical - Cell culture Actionable In a preclinical study, UNC1062 inhibited Mertk phosphorylation and downstream signaling, resulted in growth inhibition of acute myeloid leukemia cell lines in culture (PMID: 29277773). 29277773
MERTK positive acute myeloid leukemia sensitive UNC1666 Preclinical - Cell culture Actionable In a preclinical study, UNC1666 inhibited Mertk phosphorylation and downstream signaling, induced apoptosis of acute myeloid leukemia cell lines in culture (PMID: 25762638). 25762638
MERTK positive Advanced Solid Tumor predicted - sensitive RGX-019 Preclinical - Cell culture Actionable In a preclinical study, RGX-019 treatment induced Mertk internalization and degradation in tumor cell lines, leading to inhibition of colony formation in culture (AACR Annual Meeting 2019, Abstract LB-277). detail...