RET C618W
Gene Variant Detail

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Gene RET
Variant C618W
Impact List missense
Protein Effect unknown
Gene Variant Descriptions RET C618W lies within the extracellular domain of the Ret protein (UniProt.org). C618W has been identified in sequencing studies (PMID: 17384210, PMID: 14718397), but has not been biochemically characterized and therefore, its effect on Ret protein function is unknown (PubMed, Feb 2025).
Associated Drug Resistance
Category Variants Paths

RET mutant RET C618X RET C618W

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Transcript NM_020975.6
gDNA chr10:g.43113650C>G
cDNA c.1854C>G
Protein p.C618W
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_020975.6 chr10:g.43113650C>G c.1854C>G p.C618W RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43113650C>G c.1854C>G p.C618W RefSeq GRCh38/hg38
NM_020630 chr10:g.43113650C>G c.1854C>G p.C618W RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43113650C>G c.1854C>G p.C618W RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43113650C>G c.1854C>G p.C618W RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43113650C>G c.1854C>G p.C618W RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43113650C>G c.1854C>G p.C618W RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43113650C>G c.1854C>G p.C618W RefSeq GRCh38/hg38
NM_020975 chr10:g.43113650C>G c.1854C>G p.C618W RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43113650C>G c.1854C>G p.C618W RefSeq GRCh38/hg38
NM_001406763.1 chr10:g.43113650C>G c.1854C>G p.C618W RefSeq GRCh38/hg38
NM_001406765.1 chr10:g.43113650C>G c.1854C>G p.C618W RefSeq GRCh38/hg38

Filtering

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RET C618W medullary thyroid carcinoma sensitive Selpercatinib FDA approved - On Companion Diagnostic Actionable In a Phase I/II trial (LIBRETTO-001) that supported FDA approval, Retevmo (selpercatinib) treatment resulted in an objective response rate (ORR) of 69% (38/55, 5 complete and 33 partial responses) in previously treated adult and pediatric patients of 12 years and older with medullary thyroid cancer harboring RET mutations as detected by an approved test, including RET C618W; ORR was 73% (64/88) in treatment naive patients (PMID: 32846061; NCT03157128). detail... 32846061 detail...