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RET C634L - Gene Variant Detail

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Gene RET
Variant C634L
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions RET C634L lies within the cysteine-rich region of the Ret protein (PMID: 9879991). C634L results in ligand-independent dimerization of Ret and increased cell proliferation in culture (PMID: 27841748).
Associated Drug Resistance
Category Variants Paths

RET mutant RET act mut RET C634L

RET mutant RET C634X RET C634L

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Transcript NM_020975.6
gDNA chr10:g.43114500_43114501delTGinsCT
cDNA c.1900_1901delTGinsCT
Protein p.C634L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_020975 chr10:g.43114500_43114501delTGinsCT c.1900_1901delTGinsCT p.C634L RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43114500_43114501delTGinsCT c.1900_1901delTGinsCT p.C634L RefSeq GRCh38/hg38
NM_020630 chr10:g.43114500_43114501delTGinsCT c.1900_1901delTGinsCT p.C634L RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43114500_43114501delTGinsCT c.1900_1901delTGinsCT p.C634L RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43114500_43114501delTGinsCT c.1900_1901delTGinsCT p.C634L RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43114500_43114501delTGinsCT c.1900_1901delTGinsCT p.C634L RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43114500_43114501delTGinsCT c.1900_1901delTGinsCT p.C634L RefSeq GRCh38/hg38
NM_001406783.1 chr10:g.43123795_43123796delTGinsCT c.1900_1901delTGinsCT p.C634L RefSeq GRCh38/hg38
NM_001406786.1 chr10:g.43123795_43123796delTGinsCT c.1900_1901delTGinsCT p.C634L RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43114500_43114501delTGinsCT c.1900_1901delTGinsCT p.C634L RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43114500_43114501delTGinsCT c.1900_1901delTGinsCT p.C634L RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43114500_43114501delTGinsCT c.1900_1901delTGinsCT p.C634L RefSeq GRCh38/hg38

Filtering

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References