Gene Variant Detail

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Gene MSH3
Variant loss
Impact List unknown
Protein Effect loss of function
Gene Variant Descriptions MSH3 loss indicates loss of the MSH3 gene, mRNA, and protein.
Associated Drug Resistance
Category Variants Paths

MSH3 mutant MSH3 inact mut MSH3 loss

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No Variant Reference Transcript is Available.
No transcript is Available.

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
MSH3 loss colon cancer sensitive KU60648 + Radiotherapy Preclinical - Cell culture Actionable In a preclinical study, KU60648 combined with irradiation resulted in enhanced sensitivity compared to KU60648 alone in MSH3 deficient colon cancer cells in culture, demonstrating reduced colony formation (PMID: 28224663). 28224663
MSH3 loss colorectal cancer predicted - sensitive Olaparib Preclinical - Cell culture Actionable In a preclinical study, MSH3-deficient colorectal cancer cells demonstrated increased sensitivity to growth inhibition by Lynparza (olaparib) compared to cells expressing MSH3 in culture (PMID: 21285347). 21285347