RAD51C del
Gene Variant Detail

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Gene RAD51C
Variant del
Impact List deletion
Protein Effect loss of function
Gene Variant Descriptions RAD51C del indicates a deletion of the RAD51C gene.
Associated Drug Resistance
Category Variants Paths

RAD51C mutant RAD51C inact mut RAD51C del

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No Variant Reference Transcript is Available.
No transcript is Available.

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RAD51C del ovarian cancer sensitive Saruparib Preclinical - Cell culture Actionable In a preclinical study, Saruparib (AZD5305) inhibited colony formation in an ovarian cancer cell line with RAD51C deletion in culture (PMID: 35929986). 35929986
RAD51C del ovarian cancer predicted - sensitive unspecified PARP inhibitor Case Reports/Case Series Actionable In a clinical study, PARP inhibitor monotherapy (niraparib (n=1), olaparib (n=5) or rucaparib (n=2)), resulted in a median progression-free survival (PFS) of 25.4 mo and an overall survival (OS) of 51.8 mo in ovarian cancer patients with homozygous deletion of homologous recombination repair (HRR) genes (n=8) including RAD51C (n=1), compared to a median PFS of 4.9 mo and OS of 18.5 mo in patients without HRR gene alterations (n=198) (PMID: 42133897). 42133897