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Profile Name | RAD51C del |
Gene Variant Detail | |
Relevant Treatment Approaches | Olaparib |
Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|---|
RAD51C del | ovarian cancer | sensitive | Saruparib | Preclinical - Cell culture | Actionable | In a preclinical study, Saruparib (AZD5305) inhibited colony formation in an ovarian cancer cell line with RAD51C deletion in culture (PMID: 35929986). | 35929986 |