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Gene RAD51C
Variant G153D
Impact List missense
Protein Effect unknown
Gene Variant Descriptions RAD51C G153D does not lie within any known functional domains of the Rad51c protein (UniProt.org). G153D results in reduced homologous recombination activity compared to wild-type Rad51c in cell culture (PMID: 36099300) and decreased interaction with Xrcc3, Rad51b, and Rad51d in a yeast assay but rescues survival in Rad51c-null cells in culture (PMID: 21980511, PMID: 36099300), and therefore, its effect on Rad51c protein function is unknown.
Associated Drug Resistance
Category Variants Paths

RAD51C mutant RAD51C G153D

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Transcript NM_058216.3
gDNA chr17:g.58696746G>A
cDNA c.458G>A
Protein p.G153D
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_058216.3 chr17:g.58696746G>A c.458G>A p.G153D RefSeq GRCh38/hg38
XM_006722002 chr17:g.58696746G>A c.458G>A p.G153D RefSeq GRCh38/hg38
XM_006722001.4 chr17:g.58696746G>A c.458G>A p.G153D RefSeq GRCh38/hg38
XM_006722001.5 chr17:g.58696746G>A c.458G>A p.G153D RefSeq GRCh38/hg38
NM_058216.2 chr17:g.58696746G>A c.458G>A p.G153D RefSeq GRCh38/hg38
XM_006722001 chr17:g.58696746G>A c.458G>A p.G153D RefSeq GRCh38/hg38
XM_047436505.1 chr17:g.58696746G>A c.458G>A p.G153D RefSeq GRCh38/hg38
NM_058216 chr17:g.58696746G>A c.458G>A p.G153D RefSeq GRCh38/hg38
XM_006722002.5 chr17:g.58696746G>A c.458G>A p.G153D RefSeq GRCh38/hg38
XM_006722002.4 chr17:g.58696746G>A c.458G>A p.G153D RefSeq GRCh38/hg38

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RAD51C G153D Advanced Solid Tumor sensitive Olaparib Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C G153D sensitized RAD51C-deficient cells to Lynparza (olaparib) treatment in culture, resulting in decreased cell proliferation (PMID: 37253112). 37253112
RAD51C G153D Advanced Solid Tumor sensitive Cisplatin Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C G153D sensitized RAD51C-deficient cells to Platinol (cisplatin) treatment in culture, resulting in decreased cell proliferation (PMID: 37253112). 37253112