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Gene RET
Variant A883X
Impact List missense
Protein Effect unknown
Gene Variant Descriptions RET A883X indicates any Ret missense mutation that results in replacement of the alanine (A) at amino acid 883 by a different amino acid.
Associated Drug Resistance
Category Variants Paths

RET mutant RET A883X

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Transcript NM_020975.6
gDNA chr10:g.43120120_43120122
cDNA c.2647_2649
Protein p.A883
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_020630 chr10:g.43120120_43120122 c.2647_2649 p.A883 RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43120120_43120122 c.2647_2649 p.A883 RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43120120_43120122 c.2647_2649 p.A883 RefSeq GRCh38/hg38
NM_020975 chr10:g.43120120_43120122 c.2647_2649 p.A883 RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43120120_43120122 c.2647_2649 p.A883 RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43120120_43120122 c.2647_2649 p.A883 RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43120120_43120122 c.2647_2649 p.A883 RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43120120_43120122 c.2647_2649 p.A883 RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43120120_43120122 c.2647_2649 p.A883 RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43120120_43120122 c.2647_2649 p.A883 RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RET A883X medullary thyroid carcinoma not applicable N/A Guideline Risk Factor Germline RET A883X mutations result in multiple endocrine neoplasia, type 2B (MEN 2B), which is associated with high risk of developing thyroid medullary carcinoma (NCCN.org). detail...