RET M918X
Gene Variant Detail

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Gene RET
Variant M918X
Impact List missense
Protein Effect unknown
Gene Variant Descriptions RET M918X indicates any Ret missense mutation that results in replacement of the methionine (M) at amino acid 918 by a different amino acid.
Associated Drug Resistance
Category Variants Paths

RET mutant RET M918X

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Transcript NM_020975.6
gDNA chr10:g.43121967_43121969
cDNA c.2752_2754
Protein p.M918
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001406759.1 chr10:g.43121967_43121969 c.2752_2754 p.M918 RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43121967_43121969 c.2752_2754 p.M918 RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43121967_43121969 c.2752_2754 p.M918 RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43121967_43121969 c.2752_2754 p.M918 RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43121967_43121969 c.2752_2754 p.M918 RefSeq GRCh38/hg38
NM_020630 chr10:g.43121967_43121969 c.2752_2754 p.M918 RefSeq GRCh38/hg38
NM_020975 chr10:g.43121967_43121969 c.2752_2754 p.M918 RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43121967_43121969 c.2752_2754 p.M918 RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43121967_43121969 c.2752_2754 p.M918 RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43121967_43121969 c.2752_2754 p.M918 RefSeq GRCh38/hg38
NM_001406771.1 chr10:g.43128114_43128116 c.2752_2754 p.M918 RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RET M918X medullary thyroid carcinoma not applicable N/A Guideline Risk Factor Germline RET M918X mutations result in multiple endocrine neoplasia, type 2B (MEN 2B), which is associated with high risk of developing thyroid medullary carcinoma (NCCN.org). detail...