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Gene RET
Variant C611X
Impact List missense
Protein Effect unknown
Gene Variant Descriptions RET C611X indicates any Ret missense mutation that results in replacement of the cysteine (C) at amino acid 611 by a different amino acid.
Associated Drug Resistance
Category Variants Paths

RET mutant RET C611X

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Transcript NM_020975.6
gDNA chr10:g.43113627_43113629
cDNA c.1831_1833
Protein p.C611
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_020630 chr10:g.43113627_43113629 c.1831_1833 p.C611 RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43113627_43113629 c.1831_1833 p.C611 RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43113627_43113629 c.1831_1833 p.C611 RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43113627_43113629 c.1831_1833 p.C611 RefSeq GRCh38/hg38
NM_001406765.1 chr10:g.43113627_43113629 c.1831_1833 p.C611 RefSeq GRCh38/hg38
NM_001406763.1 chr10:g.43113627_43113629 c.1831_1833 p.C611 RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43113627_43113629 c.1831_1833 p.C611 RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43113627_43113629 c.1831_1833 p.C611 RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43113627_43113629 c.1831_1833 p.C611 RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43113627_43113629 c.1831_1833 p.C611 RefSeq GRCh38/hg38
NM_020975 chr10:g.43113627_43113629 c.1831_1833 p.C611 RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43113627_43113629 c.1831_1833 p.C611 RefSeq GRCh38/hg38

Filtering

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RET C611X medullary thyroid carcinoma not applicable N/A Guideline Risk Factor Germline RET C611X mutations result in multiple endocrine neoplasia, type 2A (MEN 2A), which is associated with high risk of developing thyroid medullary carcinoma (NCCN.org). detail...