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Gene RET
Variant C618X
Impact List missense
Protein Effect unknown
Gene Variant Descriptions RET C618X indicates any Ret missense mutation that results in replacement of the cysteine (C) at amino acid 618 by a different amino acid.
Associated Drug Resistance
Category Variants Paths

RET mutant RET C618X

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Transcript NM_020975.6
gDNA chr10:g.43113648_43113650
cDNA c.1852_1854
Protein p.C618
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001406743.1 chr10:g.43113648_43113650 c.1852_1854 p.C618 RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43113648_43113650 c.1852_1854 p.C618 RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43113648_43113650 c.1852_1854 p.C618 RefSeq GRCh38/hg38
NM_020630 chr10:g.43113648_43113650 c.1852_1854 p.C618 RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43113648_43113650 c.1852_1854 p.C618 RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43113648_43113650 c.1852_1854 p.C618 RefSeq GRCh38/hg38
NM_001406765.1 chr10:g.43113648_43113650 c.1852_1854 p.C618 RefSeq GRCh38/hg38
NM_020975 chr10:g.43113648_43113650 c.1852_1854 p.C618 RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43113648_43113650 c.1852_1854 p.C618 RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43113648_43113650 c.1852_1854 p.C618 RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43113648_43113650 c.1852_1854 p.C618 RefSeq GRCh38/hg38
NM_001406763.1 chr10:g.43113648_43113650 c.1852_1854 p.C618 RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
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Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RET C618X medullary thyroid carcinoma not applicable N/A Guideline Risk Factor Germline RET C618X mutations result in multiple endocrine neoplasia, type 2A (MEN 2A), which is associated with high risk of developing thyroid medullary carcinoma (NCCN.org). detail...