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Gene RET
Variant C620X
Impact List missense
Protein Effect unknown
Gene Variant Descriptions RET C620X indicates any Ret missense mutation that results in replacement of the cysteine (C) at amino acid 620 by a different amino acid.
Associated Drug Resistance
Category Variants Paths

RET mutant RET C620X

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Transcript NM_020975.6
gDNA chr10:g.43113654_43113656
cDNA c.1858_1860
Protein p.C620
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_020975.6 chr10:g.43113654_43113656 c.1858_1860 p.C620 RefSeq GRCh38/hg38
NM_001406763.1 chr10:g.43113654_43113656 c.1858_1860 p.C620 RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43113654_43113656 c.1858_1860 p.C620 RefSeq GRCh38/hg38
NM_001406765.1 chr10:g.43113654_43113656 c.1858_1860 p.C620 RefSeq GRCh38/hg38
NM_020975 chr10:g.43113654_43113656 c.1858_1860 p.C620 RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43113654_43113656 c.1858_1860 p.C620 RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43113654_43113656 c.1858_1860 p.C620 RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43113654_43113656 c.1858_1860 p.C620 RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43113654_43113656 c.1858_1860 p.C620 RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43113654_43113656 c.1858_1860 p.C620 RefSeq GRCh38/hg38
NM_020630 chr10:g.43113654_43113656 c.1858_1860 p.C620 RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43113654_43113656 c.1858_1860 p.C620 RefSeq GRCh38/hg38

Filtering

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Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RET C620X medullary thyroid carcinoma not applicable N/A Guideline Risk Factor Germline RET C620X mutations result in multiple endocrine neoplasia, type 2A (MEN 2A), which is associated with high risk of developing thyroid medullary carcinoma (NCCN.org). detail...