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Gene RET
Variant C634X
Impact List missense
Protein Effect unknown
Gene Variant Descriptions RET C634X indicates any Ret missense mutation that results in replacement of the cysteine (C) at amino acid 634 by a different amino acid.
Associated Drug Resistance
Category Variants Paths

RET mutant RET C634X

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Transcript NM_020975.6
gDNA chr10:g.43114500_43114502
cDNA c.1900_1902
Protein p.C634
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_020975.5 chr10:g.43114500_43114502 c.1900_1902 p.C634 RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43114500_43114502 c.1900_1902 p.C634 RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43114500_43114502 c.1900_1902 p.C634 RefSeq GRCh38/hg38
NM_001406783.1 chr10:g.43123795_43123797 c.1900_1902 p.C634 RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43114500_43114502 c.1900_1902 p.C634 RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43114500_43114502 c.1900_1902 p.C634 RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43114500_43114502 c.1900_1902 p.C634 RefSeq GRCh38/hg38
NM_020630 chr10:g.43114500_43114502 c.1900_1902 p.C634 RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43114500_43114502 c.1900_1902 p.C634 RefSeq GRCh38/hg38
NM_001406786.1 chr10:g.43123795_43123797 c.1900_1902 p.C634 RefSeq GRCh38/hg38
NM_020975 chr10:g.43114500_43114502 c.1900_1902 p.C634 RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43114500_43114502 c.1900_1902 p.C634 RefSeq GRCh38/hg38

Filtering

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RET C634X medullary thyroid carcinoma not applicable N/A Guideline Risk Factor Germline RET C634X mutations result in multiple endocrine neoplasia, type 2A (MEN 2A), which is associated with high risk of developing thyroid medullary carcinoma (NCCN.org). detail...
RET C634X medullary thyroid carcinoma sensitive Pralsetinib Phase Ib/II Actionable In a Phase I/II trial (ARROW), Gavreto (pralsetinib) treatment was well-tolerated, and resulted in an overall response rate (ORR) of 65% (51/79, 5% complete response, 59% partial response) in patients with advanced or metastatic medullary thyroid cancer harboring RET mutations, 28% of the patients harbored RET C634X (Ann Oncol. Vol 31, Supplement 4, S1084, Sep 1, 2020; NCT03037385). detail...