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Gene RET
Variant E768X
Impact List missense
Protein Effect unknown
Gene Variant Descriptions RET E768X indicates any Ret missense mutation that results in replacement of the glutamic acid (E) at amino acid 768 by a different amino acid.
Associated Drug Resistance
Category Variants Paths

RET mutant RET E768X

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Transcript NM_020975.6
gDNA chr10:g.43118390_43118392
cDNA c.2302_2304
Protein p.E768
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_020630.7 chr10:g.43118390_43118392 c.2302_2304 p.E768 RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43118390_43118392 c.2302_2304 p.E768 RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43118390_43118392 c.2302_2304 p.E768 RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43118390_43118392 c.2302_2304 p.E768 RefSeq GRCh38/hg38
NM_001406774.1 chr10:g.43123696_43123698 c.2302_2304 p.E768 RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43118390_43118392 c.2302_2304 p.E768 RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43118390_43118392 c.2302_2304 p.E768 RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43118390_43118392 c.2302_2304 p.E768 RefSeq GRCh38/hg38
NM_020630 chr10:g.43118390_43118392 c.2302_2304 p.E768 RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43118390_43118392 c.2302_2304 p.E768 RefSeq GRCh38/hg38
NM_020975 chr10:g.43118390_43118392 c.2302_2304 p.E768 RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
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Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RET E768X medullary thyroid carcinoma not applicable N/A Guideline Risk Factor Germline RET E768X mutations result in multiple endocrine neoplasia, type 2A (MEN 2A), which is associated with increased risk of developing thyroid medullary carcinoma (NCCN.org). detail...