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Gene RET
Variant L790X
Impact List missense
Protein Effect unknown
Gene Variant Descriptions RET L790X indicates any Ret missense mutation that results in replacement of the leucine (L) at amino acid 790 by a different amino acid.
Associated Drug Resistance
Category Variants Paths

RET mutant RET L790X

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Transcript NM_020975.6
gDNA chr10:g.43118456_43118458
cDNA c.2368_2370
Protein p.L790
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001406744.1 chr10:g.43118456_43118458 c.2368_2370 p.L790 RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43118456_43118458 c.2368_2370 p.L790 RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43118456_43118458 c.2368_2370 p.L790 RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43118456_43118458 c.2368_2370 p.L790 RefSeq GRCh38/hg38
NM_020975 chr10:g.43118456_43118458 c.2368_2370 p.L790 RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43118456_43118458 c.2368_2370 p.L790 RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43118456_43118458 c.2368_2370 p.L790 RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43118456_43118458 c.2368_2370 p.L790 RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43118456_43118458 c.2368_2370 p.L790 RefSeq GRCh38/hg38
NM_020630 chr10:g.43118456_43118458 c.2368_2370 p.L790 RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RET L790X medullary thyroid carcinoma not applicable N/A Guideline Risk Factor Germline RET L790X mutations result in multiple endocrine neoplasia, type 2A (MEN 2A), which is associated with increased risk of developing thyroid medullary carcinoma (NCCN.org). detail...