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Gene RET
Variant Y791X
Impact List missense
Protein Effect unknown
Gene Variant Descriptions RET Y791X indicates any Ret missense mutation that results in replacement of the tyrosine (Y) at amino acid 791 by a different amino acid.
Associated Drug Resistance
Category Variants Paths

RET mutant RET Y791X

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Transcript NM_020975.6
gDNA chr10:g.43118459_43118461
cDNA c.2371_2373
Protein p.Y791
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_020630 chr10:g.43118459_43118461 c.2371_2373 p.Y791 RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43118459_43118461 c.2371_2373 p.Y791 RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43118459_43118461 c.2371_2373 p.Y791 RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43118459_43118461 c.2371_2373 p.Y791 RefSeq GRCh38/hg38
NM_001406780.1 chr10:g.43128192_43128194 c.2371_2373 p.Y791 RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43118459_43118461 c.2371_2373 p.Y791 RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43118459_43118461 c.2371_2373 p.Y791 RefSeq GRCh38/hg38
NM_001406779.1 chr10:g.43128192_43128194 c.2371_2373 p.Y791 RefSeq GRCh38/hg38
NM_020975 chr10:g.43118459_43118461 c.2371_2373 p.Y791 RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43118459_43118461 c.2371_2373 p.Y791 RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43118459_43118461 c.2371_2373 p.Y791 RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43118459_43118461 c.2371_2373 p.Y791 RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RET Y791X medullary thyroid carcinoma not applicable N/A Guideline Risk Factor Germline RET Y791X mutations result in multiple endocrine neoplasia, type 2A (MEN 2A), which is associated with increased risk of developing thyroid medullary carcinoma (NCCN.org). detail...