RET S891X
Gene Variant Detail

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Gene RET
Variant S891X
Impact List missense
Protein Effect unknown
Gene Variant Descriptions RET S891X indicates any Ret missense mutation that results in replacement of the serine (S) at amino acid 891 by a different amino acid.
Associated Drug Resistance
Category Variants Paths

RET mutant RET S891X

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Transcript NM_020975.6
gDNA chr10:g.43120144_43120146
cDNA c.2671_2673
Protein p.S891
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_020975 chr10:g.43120144_43120146 c.2671_2673 p.S891 RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43120144_43120146 c.2671_2673 p.S891 RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43120144_43120146 c.2671_2673 p.S891 RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43120144_43120146 c.2671_2673 p.S891 RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43120144_43120146 c.2671_2673 p.S891 RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43120144_43120146 c.2671_2673 p.S891 RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43120144_43120146 c.2671_2673 p.S891 RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43120144_43120146 c.2671_2673 p.S891 RefSeq GRCh38/hg38
NM_020630 chr10:g.43120144_43120146 c.2671_2673 p.S891 RefSeq GRCh38/hg38
NM_001406765.1 chr10:g.43123675_43123677 c.2671_2673 p.S891 RefSeq GRCh38/hg38
NM_001406774.1 chr10:g.43126731_43126733 c.2671_2673 p.S891 RefSeq GRCh38/hg38
NM_001406763.1 chr10:g.43123675_43123677 c.2671_2673 p.S891 RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43120144_43120146 c.2671_2673 p.S891 RefSeq GRCh38/hg38

Filtering

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RET S891X medullary thyroid carcinoma not applicable N/A Guideline Risk Factor Germline RET S891X mutations result in multiple endocrine neoplasia, type 2A (MEN 2A), which is associated with increased risk of developing thyroid medullary carcinoma (NCCN.org). detail...