BRAF E451K
Gene Variant Detail

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Gene BRAF
Variant E451K
Impact List missense
Protein Effect unknown
Gene Variant Descriptions BRAF E451K does not lie within any known functional domains of the Braf protein (UniProt.org). E451K results in a slight increase of Erk phosphorylation in culture (PMID: 31158244). but has not been fully biochemically characterized and therefore, its effect on Braf protein function is unknown.
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF E451K

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Transcript NM_004333.6
gDNA chr7:g.140781657C>T
cDNA c.1351G>A
Protein p.E451K
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004333.5 chr7:g.140781657C>T c.1351G>A p.E451K RefSeq GRCh38/hg38
XM_047420769.1 chr7:g.140781657C>T c.1351G>A p.E451K RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140781657C>T c.1351G>A p.E451K RefSeq GRCh38/hg38
XM_005250045 chr7:g.140781657C>T c.1351G>A p.E451K RefSeq GRCh38/hg38
NM_004333 chr7:g.140781657C>T c.1351G>A p.E451K RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140781657C>T c.1351G>A p.E451K RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140781657C>T c.1351G>A p.E451K RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140781657C>T c.1351G>A p.E451K RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140781657C>T c.1351G>A p.E451K RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF E451K breast cancer predicted - resistant Dabrafenib Preclinical Actionable In a preclinical study, Tafinlar (dabrafenib) treatment resulted in increased Erk phosphorylation in breast cancer cells expressing BRAF E451K in culture (PMID: 31158244). 31158244