POLE inact mut
Gene Variant Detail

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Gene POLE
Variant inact mut
Impact List unknown
Protein Effect loss of function
Gene Variant Descriptions POLE inact mut indicates that this variant results in a loss of function of the Pole protein. However, the specific amino acid change has not been identified.
Associated Drug Resistance
Category Variants Paths

POLE mutant POLE inact mut

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No Variant Reference Transcript is Available.
No transcript is Available.

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT06712472 Phase III Olaparib Randomized Phase III Trial Testing Maintenance Olaparib Versus Observation After Adjuvant Chemoradiation for P53abn Endometrial Cancer (RAINBO-RED) Recruiting FRA 0
NCT07227636 Phase II Balstilimab + Botensilimab A Study of Botensilimab and Balstilimab for Colorectal Cancer Recruiting USA 0
NCT06084416 Phase I AMG 650 A Study of Sovilnesib in Subjects With Ovarian Cancer Active, not recruiting USA 0
NCT02715284 Phase I Dostarlimab-gxly Study of TSR-042, an Anti-programmed Cell Death-1 Receptor (PD-1) Monoclonal Antibody, in Participants With Advanced Solid Tumors (GARNET) Active, not recruiting USA | POL | ITA | GBR | FRA | ESP | DNK | CZE | CAN | BRA 0
NCT04500548 Phase I Nivolumab Ipilimumab + Nivolumab Testing the Combination of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) in Children, Adolescent, and Young Adult Patients With Relapsed/Refractory Cancers That Have an Increased Number of Genetic Changes, The 3CI Study Withdrawn USA | CAN 0