Therapy Detail
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| Therapy Name | Balstilimab + Botensilimab |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Balstilimab | AGEN-2034|AGEN2034 | Immune Checkpoint Inhibitor 149 PD-L1/PD-1 antibody 121 | Balstilimab (AGEN2034) is a monoclonal antibody that targets PD-1 (PDCD1) and inhibits binding of the PD-L1 ligand (CD274), potentially resulting in enhanced anti-tumor immune response (Journal of Clinical Oncology 36, no. 15_suppl (May 20 2018) 3086-3086). | |
| Botensilimab | AGEN1181|AGEN 1181|AGEN-1181 | CTLA4 Antibody 31 Immune Checkpoint Inhibitor 149 | Botensilimab (AGEN1181) is an antibody that targets CTLA4, potentially resulting in increased anti-tumor immune response (Journal for ImmunoTherapy of Cancer 2021;9). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06346197 | Phase III | Fluorouracil + Leucovorin + Nivolumab + Oxaliplatin Capecitabine + Nivolumab + Oxaliplatin Balstilimab + Botensilimab | Combination of Immune Checkpoint in Locally Advanced or Metastatic MSI/dMMR Esogastric Adenocarcinomas (CIME) | Not yet recruiting | FRA | 0 |
| NCT05928806 | Phase II | Balstilimab + Botensilimab Ipilimumab + Nivolumab | Advanced Renal Cell Cancer Combination ImmunoThErapy Clinical Trial (ARCITECT) | Recruiting | USA | 0 |
| NCT05608044 | Phase II | Balstilimab + Botensilimab Botensilimab | A Study of Botensilimab and Balstilimab for the Treatment of Colorectal Cancer | Active, not recruiting | USA | ITA | FRA | ESP | BRA | BEL | 2 |
| NCT06300463 | Phase II | Balstilimab + Botensilimab + GS-1423 Balstilimab + Botensilimab | Platform Study of Immunotherapy Combinations in Colorectal Cancer Liver Metastases | Recruiting | USA | 0 |
| NCT06279130 | Phase II | Balstilimab Balstilimab + Botensilimab | Pan-tumor Neoadjuvant Basket Study of Immune Check-point Inhibition and Novel Immuno-oncology Combinations (NEOASIS) | Recruiting | NLD | 0 |
| NCT06575725 | Phase II | Balstilimab + Botensilimab + Regorafenib Balstilimab + Botensilimab | Botensilimab, Balstilimab and Regorafenib or Botensilimab and Balstilimab for the Treatment of Advanced or Metastatic Microsatellite Stable Colorectal Cancer | Not yet recruiting | USA | 0 |
| NCT06268015 | Phase II | Balstilimab + Botensilimab + Fluorouracil + Leucovorin + Oxaliplatin + Panitumumab Balstilimab + Botensilimab Balstilimab + Bevacizumab + Botensilimab + Fluorouracil + Leucovorin + Oxaliplatin | Botensilimab and Balstilimab Optimization in Colorectal Cancer (BBOpCo) | Not yet recruiting | USA | 0 |
| NCT06095674 | Phase I | Balstilimab + Botensilimab | ImmunoTHerapy Adjacent to Cervical CAncer (ITHACA) Study (ITHACA) | Not yet recruiting | NLD | 0 |
| NCT05571293 | Phase II | Balstilimab + Botensilimab | Combination Immunotherapy in Colorectal Cancer (NEST-1) | Recruiting | 0 |
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