PDGFRB D850Y
Gene Variant Detail

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Gene PDGFRB
Variant D850Y
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions PDGFRB D850Y lies within the protein kinase domain of the Pdgfrb protein (UniProt.org). D850Y results in increased autophosphorylation of Pdgfrb in cultured cells (PMID: 31031011), constitutive activation in a reporter assay (PMID: 39580648), and has been associated with resistance in a reporter assay (PMID: 39580648).
Associated Drug Resistance Y
Category Variants Paths

PDGFRB mutant PDGFRB act mut PDGFRB D850Y

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Transcript NM_002609.4
gDNA chr5:g.150120926C>A
cDNA c.2548G>T
Protein p.D850Y
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011537659 chr5:g.150120926C>A c.2548G>T p.D850Y RefSeq GRCh38/hg38
NM_002609.3 chr5:g.150120926C>A c.2548G>T p.D850Y RefSeq GRCh38/hg38
NM_002609.4 chr5:g.150120926C>A c.2548G>T p.D850Y RefSeq GRCh38/hg38
NM_002609 chr5:g.150120926C>A c.2548G>T p.D850Y RefSeq GRCh38/hg38
XM_011537658 chr5:g.150120926C>A c.2548G>T p.D850Y RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PDGFRB D850Y Advanced Solid Tumor predicted - resistant Imatinib Preclinical - Biochemical Actionable In a preclinical study, PDGFRB D850Y demonstrated resistance to inhibition of Pdgfrb activity by Gleevec (imatinib) treatment in a reporter assay in cultured cells (PMID: 39580648). 39580648
PDGFRB D850Y Advanced Solid Tumor predicted - sensitive Dasatinib Preclinical - Biochemical Actionable In a preclinical study, Sprycel (dasatinib) treatment inhibited Pdgfrb activity in a reporter assay in a cell line expressing PDGFRB D850Y (PMID: 39580648). 39580648