NRAS G12C
Gene Variant Detail

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Gene NRAS
Variant G12C
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions NRAS G12C is a hotspot mutation that lies within a GTP-binding region of the Nras protein (UniProt.org). G12C has not been characterized, but can be predicted to confer a loss of function to the Nras protein based on the effects of HRAS G12C and KRAS G12C, which result in a loss of response to GTPase-activating proteins, and transformation of cultured cells (PMID: 26037647, PMID: 6092966).
Associated Drug Resistance
Category Variants Paths

NRAS mutant NRAS act mut NRAS G12C

NRAS mutant NRAS exon2 NRAS G12X NRAS G12C

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Transcript NM_002524.5
gDNA chr1:g.114716127C>A
cDNA c.34G>T
Protein p.G12C
Source Database RefSeq
Genome Build GRCh38/hg38

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