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Gene RAD54L
Variant K189R
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions RAD54L K189R lies within the helicase ATP-binding domain of the Rad54l protein (UniProt.org). K189R confers a loss of function to the Rad54l protein as demonstrated by loss of ATPase activity (PMID: 9774452) and impaired D-loop formation (PMID: 17417655) in in vitro assays, increased sensitivity to DNA damage induction (PMID: 9774452, PMID: 21357745), and decreased displacement of Rad51 from DNA in cultured cells (PMID: 21357745).
Associated Drug Resistance
Category Variants Paths

RAD54L mutant RAD54L inact mut RAD54L K189R

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Transcript NM_001142548.2
gDNA chr1:g.46260815A>G
cDNA c.566A>G
Protein p.K189R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001142548.1 chr1:g.46260815A>G c.566A>G p.K189R RefSeq GRCh38/hg38
NM_003579.4 chr1:g.46260815A>G c.566A>G p.K189R RefSeq GRCh38/hg38
NM_003579 chr1:g.46260815A>G c.566A>G p.K189R RefSeq GRCh38/hg38
NM_001142548 chr1:g.46260815A>G c.566A>G p.K189R RefSeq GRCh38/hg38
NM_001142548.2 chr1:g.46260815A>G c.566A>G p.K189R RefSeq GRCh38/hg38
NM_003579.3 chr1:g.46260815A>G c.566A>G p.K189R RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RAD54L inact mut prostate cancer sensitive Olaparib Guideline Actionable Lynparza (olaparib) is included in guidelines as second-line therapy post androgen receptor-directed therapy for patients with metastatic castration-resistant prostate cancer harboring pathogenic mutations in RAD54L (NCCN.org). detail...
RAD54L inact mut prostate cancer sensitive Olaparib FDA approved - On Companion Diagnostic Actionable In a Phase III trial (PROfound) that supported FDA approval, Lynparza (olaparib) improved median imaging-based progression-free survival (5.8 vs 3.5 mo, HR 0.49, p<0.001) compared to control in metastatic castration-resistant prostate cancer patients harboring deleterious or suspected deleterious mutations in homologous recombination repair genes who progressed on hormone therapy, HR for progression or death was 0.33 in RAD54L-mutant patients (PMID: 32343890; NCT02987543). detail... detail... 32343890