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Gene HRAS
Variant G12C
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions HRAS G12C does not lie within any known functional domains of the Hras protein (UniProt.org). G12C results in decreased Hras GTPase activity, loss of sensitivity to GTPase-activating proteins, thus leads to transformation of cells in culture (PMID: 24224811, PMID: 6092966).
Associated Drug Resistance
Category Variants Paths

HRAS mutant HRAS act mut HRAS G12C

HRAS mutant HRAS G12X HRAS G12C

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Transcript NM_005343.4
gDNA chr11:g.534289C>A
cDNA c.34G>T
Protein p.G12C
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001130442.2 chr11:g.534289C>A c.34G>T p.G12C RefSeq GRCh38/hg38
NM_005343.4 chr11:g.534289C>A c.34G>T p.G12C RefSeq GRCh38/hg38
NM_005343 chr11:g.534289C>A c.34G>T p.G12C RefSeq GRCh38/hg38
NM_005343.3 chr11:g.534289C>A c.34G>T p.G12C RefSeq GRCh38/hg38
NM_176795.5 chr11:g.534289C>A c.34G>T p.G12C RefSeq GRCh38/hg38
NM_001130442 chr11:g.534289C>A c.34G>T p.G12C RefSeq GRCh38/hg38
NM_001130442.3 chr11:g.534289C>A c.34G>T p.G12C RefSeq GRCh38/hg38
NM_176795.4 chr11:g.534289C>A c.34G>T p.G12C RefSeq GRCh38/hg38
NM_176795 chr11:g.534289C>A c.34G>T p.G12C RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
HRAS G12C head and neck squamous cell carcinoma predicted - sensitive Tipifarnib Preclinical - Cell line xenograft Actionable In a preclinical study, a head and neck squamous cell carcinoma cell line xenograft model harboring HRAS G12C was sensitive to treatment with Zarnestra (tipifarnib), demonstrating inhibition of tumor growth and vessel formation, increased apoptotic activity, and decreased cell proliferation (PMID: 32727882). 32727882
HRAS G12C Advanced Solid Tumor sensitive Sotorasib Preclinical - Cell culture Actionable In a preclinical study, Lumakras (sotorasib) inhibited viability of cultured cells expressing HRAS G12C (PMID: 38236605). 38236605
HRAS G12C Advanced Solid Tumor sensitive JDQ443 Preclinical - Cell culture Actionable In a preclinical study, JDQ443 inhibited viability of cultured cells expressing HRAS G12C (PMID: 38236605). 38236605
HRAS G12C Advanced Solid Tumor sensitive RM-018 Preclinical - Cell culture Actionable In a preclinical study, RM-018 inhibited viability of cultured cells expressing HRAS G12C (PMID: 38236605). 38236605