Gene Variant Detail

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Gene HRAS
Variant G13R
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions HRAS G13R is hotspot mutation that lies within the GTP binding domain of the Hras protein (UniProt.org). G13R results in activation of Mapk and Pi3k signaling, increased cell proliferation in culture (PMID: 22683711), and is predicted to lead to a loss of Hras protein function based on the effects of other HRAS G13 mutations.
Associated Drug Resistance
Category Variants Paths

HRAS mutant HRAS act mut HRAS G13R

HRAS mutant HRAS G13X HRAS G13R

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Transcript NM_005343.4
gDNA chr11:g.534286C>G
cDNA c.37G>C
Protein p.G13R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_176795 chr11:g.534286C>G c.37G>C p.G13R RefSeq GRCh38/hg38
NM_001130442.2 chr11:g.534286C>G c.37G>C p.G13R RefSeq GRCh38/hg38
NM_005343.4 chr11:g.534286C>G c.37G>C p.G13R RefSeq GRCh38/hg38
NM_176795.4 chr11:g.534286C>G c.37G>C p.G13R RefSeq GRCh38/hg38
NM_001130442.3 chr11:g.534286C>G c.37G>C p.G13R RefSeq GRCh38/hg38
NM_001130442 chr11:g.534286C>G c.37G>C p.G13R RefSeq GRCh38/hg38
NM_005343 chr11:g.534286C>G c.37G>C p.G13R RefSeq GRCh38/hg38
NM_176795.5 chr11:g.534286C>G c.37G>C p.G13R RefSeq GRCh38/hg38
NM_005343.3 chr11:g.534286C>G c.37G>C p.G13R RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
HRAS G13R loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor PIK3CB inhibitor PIK3CD inhibitor PIK3CG inhibitor RAS Inhibitor (Pan)
HRAS G13R PTEN inact mut
HRAS G13R PIK3CA H1047R
ALK F1245Y HRAS G13R
BRAF G466E HRAS G13R
HRAS G13R PTEN loss