PDGFRB rearrange
Gene Variant Detail

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Gene PDGFRB
Variant rearrange
Impact List unknown
Protein Effect unknown
Gene Variant Descriptions PDGFRB rearrangement indicates an unspecified rearrangement of the PDGFRB gene.
Associated Drug Resistance
Category Variants Paths

PDGFRB mutant PDGFRB rearrange

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No Variant Reference Transcript is Available.
No transcript is Available.

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PDGFRB rearrange myelodysplastic/myeloproliferative neoplasm sensitive Imatinib FDA approved - On Companion Diagnostic Actionable Gleevec (imatinib) is FDA approved for myelodysplastic/myeloproliferative cancers that are associated with PDGFRB rearrangements and detected by a companion diagnostic (FDA.gov). detail... detail... detail...
PDGFRB rearrange Advanced Solid Tumor predicted - sensitive Imatinib Preclinical - Cell culture Actionable In a preclinical study, transformed cells expressing a PDGFRB rearrangement were sensitive to treatment with Gleevec (imatinib), demonstrating decreased colony formation and reduced cell growth in culture (PMID: 31645346). 31645346
PDGFRB rearrange myeloid and lymphoid neoplasms associated with PDGFRB rearrangement sensitive Imatinib Guideline Actionable Gleevec (imatinib) is included in guidelines for patients with a myeloid/lymphoid neoplasm with eosinophilia harboring a PDGFRB rearrangement (NCCN.org). detail...
PDGFRB rearrange childhood B-cell acute lymphoblastic leukemia not applicable N/A Guideline Prognostic PDGFRB rearrangements are associated with a poor prognosis in pediatric patients with B-cell acute lymphoblastic leukemia (NCCN.org). detail...
PDGFRB rearrange B-cell acute lymphoblastic leukemia not applicable N/A Guideline Prognostic PDGFRB rearrangements are associated with a poor prognosis in patients with B-cell acute lymphoblastic leukemia (NCCN.org). detail...
PDGFRB rearrange chronic myelomonocytic leukemia sensitive Imatinib Guideline Actionable Gleevec (imatinib) is included in guidelines for patients with chronic myelomonocytic leukemia harboring a PDGFRB rearrangement (NCCN.org). detail...