PTEN loss
Gene Variant Detail

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Gene PTEN
Variant loss
Impact List unknown
Protein Effect loss of function
Gene Variant Descriptions PTEN loss indicates a loss of the PTEN gene, mRNA, and protein, which leads to suppression of Ar-dependent gene expression (PMID: 21620777), epithelial-mesenchymal transition in cell culture (PMID: 20032390), and promotes KRAS-dependent tumor formation (PMID: 20807812), and decreased apoptosis and increased cell survival in a mouse model (PMID: 12782594). PTEN loss has been identified in a number of cancers (PMID: 30738865), including prostate cancer (PMID: 29460925) and glioblastoma (PMID: 9331071).
Associated Drug Resistance
Category Variants Paths

PTEN mutant PTEN inact mut PTEN loss

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No Variant Reference Transcript is Available.
No transcript is Available.

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
PTEN loss loss of function Akt Inhibitor (Pan) Akt1 Inhibitor Akt2 Inhibitor PI3K Inhibitor (Pan) PIK3CB inhibitor
PIK3CA R38C PTEN loss
PTEN loss VHL loss
BRAF mut PTEN loss
PIK3CA mut PTEN loss
PIK3CA D1029Y PTEN loss
PIK3CA wild-type PTEN loss
PTEN loss RB1 loss
BRAF V600E PTEN loss
BRAF V600D PTEN loss
BRAF V600E PTEN loss TP53 wild-type
PIK3CA R88L PIK3CA E453del PIK3CA T1052K PTEN loss PTEN mut
PIK3CA H1047R PTEN loss
PIK3CA E542K PTEN loss
PTEN loss TP53 loss
PIK3CA E545K PTEN loss
BRAF V600E/K PTEN loss
CDKN2A loss PIK3CA E542K PTEN loss
PIK3CA act mut PTEN loss
HRAS G13R PTEN loss