RET E623_L633del
Gene Variant Detail

Request Content

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Gene RET
Variant E623_L633del
Impact List deletion
Protein Effect unknown
Gene Variant Descriptions RET E623_L633del results in the deletion of 11 amino acids in the extracellular domain of the Ret protein from amino acids 623 to 633 (UniProt.org). E623_L633del has not been characterized in the scientific literature and therefore, its effect on Ret protein function is unknown (PubMed, Jul 2025).
Associated Drug Resistance
Category Variants Paths

RET mutant RET E623_L633del

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Transcript NM_020975.6
gDNA chr10:g.43113663_43114499del837
cDNA c.1867_1899del837
Protein p.E623_L633del
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_020975.6 chr10:g.43113663_43114499del837 c.1867_1899del837 p.E623_L633del RefSeq GRCh38/hg38
NM_020975 chr10:g.43113663_43114499del837 c.1867_1899del837 p.E623_L633del RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43113663_43114499del837 c.1867_1899del837 p.E623_L633del RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43113663_43114499del837 c.1867_1899del837 p.E623_L633del RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43113663_43114499del837 c.1867_1899del837 p.E623_L633del RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43113663_43114499del837 c.1867_1899del837 p.E623_L633del RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43113663_43114499del837 c.1867_1899del837 p.E623_L633del RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43113663_43114499del837 c.1867_1899del837 p.E623_L633del RefSeq GRCh38/hg38
NM_020630 chr10:g.43113663_43114499del837 c.1867_1899del837 p.E623_L633del RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43113663_43114499del837 c.1867_1899del837 p.E623_L633del RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RET E623_L633del medullary thyroid carcinoma sensitive Selpercatinib FDA approved - On Companion Diagnostic Actionable In a Phase I/II trial (LIBRETTO-001) that supported FDA approval, Retevmo (selpercatinib) treatment resulted in an objective response rate (ORR) of 69% (38/55, 5 complete and 33 partial responses) in previously treated adult and pediatric patients of 12 years and older with medullary thyroid cancer harboring RET mutations as detected by an approved test, including RET E623_L633del; ORR was 73% (64/88) in treatment naive patients (PMID: 32846061; NCT03157128). detail... detail... 32846061