Gene Variant Detail

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Gene STK11
Variant K262Sfs*25
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions STK11 K262Sfs*25 indicates a shift in the reading frame starting at amino acid 262 and terminating 257 residues downstream causing a premature truncation of the 433 amino acid Stk11 protein (UniProt.org). K262Sfs*25 has not been characterized however, due to the effects of other truncation mutations downstream of K262 (PMID: 23612973), is predicted to lead to a loss of Stk11 protein function.
Associated Drug Resistance
Category Variants Paths

STK11 mutant STK11 inact mut STK11 K262Sfs*25

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Transcript NM_000455.5
gDNA chr19:g.1221263delA
cDNA c.785delA
Protein p.K262Sfs*25
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000455.4 chr19:g.1221263delA c.785delA p.K262Sfs*25 RefSeq GRCh38/hg38
NM_000455.5 chr19:g.1221263delA c.785delA p.K262Sfs*25 RefSeq GRCh38/hg38
XM_005259618.3 chr19:g.1221263delA c.785delA p.K262Sfs*25 RefSeq GRCh38/hg38
NM_001407255.1 chr19:g.1221263delA c.785delA p.K262Sfs*25 RefSeq GRCh38/hg38
XM_005259617.3 chr19:g.1221263delA c.785delA p.K262Sfs*25 RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
STK11 K262Sfs*25 gallbladder carcinoma no benefit Everolimus Case Reports/Case Series Actionable In a clinical case study, treatment with Afinitor (everolimus) resulted in disease progression in a patient with gallbladder carcinoma harboring STK11 K262Sfs*25 and ATM S1905Ifs*25 who had previously progressed on Lynparza (olaparib) treatment after a 13 month progression-free survival (PMID: 32045060). 32045060