Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
Profile Name | STK11 K262Sfs*25 |
Gene Variant Detail | |
Relevant Treatment Approaches |
Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|---|
STK11 K262Sfs*25 | gallbladder carcinoma | no benefit | Everolimus | Case Reports/Case Series | Actionable | In a clinical case study, treatment with Afinitor (everolimus) resulted in disease progression in a patient with gallbladder carcinoma harboring STK11 K262Sfs*25 and ATM S1905Ifs*25 who had previously progressed on Lynparza (olaparib) treatment after a 13 month progression-free survival (PMID: 32045060). | 32045060 |