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Gene RET
Variant T930K
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions RET T930K lies within the protein kinase domain of the Ret protein (UniProt.org). T930K results in Erk phosphorylation similar to wild-type Ret but cytokine-independent growth in culture (PMID: 32284345), and therefore, is predicted to lead to a gain of Ret protein function.
Associated Drug Resistance
Category Variants Paths

RET mutant RET act mut RET T930K

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Transcript NM_020975.6
gDNA chr10:g.43122004C>A
cDNA c.2789C>A
Protein p.T930K
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001406759.1 chr10:g.43122004C>A c.2789C>A p.T930K RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43122004C>A c.2789C>A p.T930K RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43122004C>A c.2789C>A p.T930K RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43122004C>A c.2789C>A p.T930K RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43122004C>A c.2789C>A p.T930K RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43122004C>A c.2789C>A p.T930K RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43122004C>A c.2789C>A p.T930K RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43122004C>A c.2789C>A p.T930K RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RET T930K Advanced Solid Tumor sensitive Selpercatinib Preclinical - Cell culture Actionable In a preclinical study, Retevmo (selpercatinib) inhibited growth of transformed cells expressing RET T930K in culture (PMID: 32284345). 32284345
RET T930K Advanced Solid Tumor sensitive Pralsetinib Preclinical - Cell culture Actionable In a preclinical study, Gavreto (pralsetinib) inhibited growth of transformed cells expressing RET T930K in culture (PMID: 32284345). 32284345