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Gene | BRAF |
Variant | K601_W604del |
Impact List | deletion |
Protein Effect | unknown |
Gene Variant Descriptions | BRAF K601_W604del results in the deletion of four amino acids in the protein kinase domain of the Braf protein from amino acids 601 to 604 (UniProt.org). K601_W604del has been identified in the scientific literature (PMID: 35598548), but has not been biochemically characterized and therefore, its effect on Braf protein function is unknown (PubMed, Aug 2024). |
Associated Drug Resistance | |
Category Variants Paths |
BRAF mutant BRAF K601_W604del |
Transcript | NM_004333.6 |
gDNA | chr7:g.140753324_140753335del12 |
cDNA | c.1802_1813del12 |
Protein | p.K601_W604del |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_004333.6 | chr7:g.140753324_140753335del12 | c.1802_1813del12 | p.K601_W604del | RefSeq | GRCh38/hg38 |
NM_001378468.1 | chr7:g.140753324_140753335del12 | c.1802_1813del12 | p.K601_W604del | RefSeq | GRCh38/hg38 |
NM_001378474.1 | chr7:g.140753324_140753335del12 | c.1802_1813del12 | p.K601_W604del | RefSeq | GRCh38/hg38 |
NM_001354609.2 | chr7:g.140753324_140753335del12 | c.1802_1813del12 | p.K601_W604del | RefSeq | GRCh38/hg38 |
Molecular Profile | Protein Effect | Treatment Approaches |
---|---|---|
BRAF K601_W604del | unknown | |
BRAF V600E BRAF K601_W604del |